Basic Information
VIS ID
TVIS44030324
Fusion event
HTLV-1-MGAT4C integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr12
Cytoband
q21.32
Reference genome
NCBI36/hg18
Start
85631794/86713886 (Hg38)
End
85631794/86713886 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
MGAT4C
miRNAs that regulate target gene
hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-5584-5p ; hsa-mir-607 ; hsa-mir-1277-5p ; hsa-mir-496 ; hsa-mir-656-3p ; hsa-mir-410-3p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-4666a-5p ; hsa-mir-5011-5p ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-4789-3p ; hsa-mir-4719 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-4797-5p ; hsa-mir-8485 ; hsa-mir-377-3p ; hsa-mir-3614-3p ; hsa-mir-1287-3p
Nearest miRNA
hsa-let-7i/Upstream/5555425; hsa-mir-1178/Downstream/31182;
Nearest TSS
ENST00000382841/Upstream/112582; ENST00000551280/Downstream/124999;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/1432964, chr12-CpG: 52/Downstream/1321442
Upstream sequence
aagtcccatagcttgaaagtgaaggagaaaagatttgactttaggcCTCAGCACCTACGGACTTATGTATTACATTATTATGTAATTCAGAGCCCCCTTT
Downstream sequence
AGTTATTAATTCATATTTTAAACATTTATTATATTGGCCTGTGATGTAGACAGGTATGCTAGAAGCATATTAGAAAATGGTTTGCACATAGTATGTTTTA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate