Basic Information
VIS ID
TVIS44030328
Fusion event
HTLV-1-USP8 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr15
Cytoband
q21.2
Reference genome
NCBI36/hg18
Start
48544962/50465473 (Hg38)
End
48544962/50465473 (Hg38)
Orient
-
Location type
Intronic
Target gene
USP8
miRNAs that regulate target gene
hsa-mir-374a-5p ; hsa-mir-125b-5p ; hsa-mir-183-5p ; hsa-mir-16-5p ; hsa-mir-155-5p ; hsa-mir-466 ; hsa-mir-95-5p ; hsa-mir-4789-3p ; hsa-mir-4643 ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-15a-3p ; hsa-mir-8066 ; hsa-mir-6768-3p ; hsa-mir-4753-5p ; hsa-mir-132-3p ; hsa-mir-212-3p
Nearest miRNA
hsa-mir-10393/Upstream/105063; hsa-mir-11181/Downstream/776717;
Nearest TSS
ENST00000557528/Upstream/6970; ENST00000561206/Downstream/24021;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/40844, chr15-CpG: 84/Downstream/220673
Upstream sequence
taggagcagaggtttaataggcaaaagaaagagaaagaagaactgctctctcacttttgagagtgaggggtgcccaagtgggATTTCCCTAAATCTTTGC
Downstream sequence
TTCTTAAAGACACACTCCACCCTTTTTGAAGGTTGAAGTTACGGATTTGCCAACTTTTGATTTGGCTGTTTTCTCCTATTGGTGGTATTTAGAATCTTAT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate