Basic Information
VIS ID
TVIS44030341
Fusion event
HTLV-1-CDKN3 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr14
Cytoband
q22.2
Reference genome
NCBI36/hg18
Start
53951008/54414540 (Hg38)
End
53951008/54414540 (Hg38)
Orient
+
Location type
Intronic
Target gene
CDKN3
miRNAs that regulate target gene
hsa-mir-146a-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-92a-3p ; hsa-mir-6819-3p ; hsa-mir-3689d ; hsa-mir-7641 ; hsa-mir-4284 ; hsa-mir-4695-3p ; hsa-mir-4772-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-1304-3p ; hsa-mir-6741-3p ; hsa-mir-331-3p ; hsa-mir-6810-3p ; hsa-mir-6801-3p ; hsa-mir-6890-3p
Nearest miRNA
hsa-mir-208a/Upstream/466056; hsa-mir-1185-1/Downstream/463573;
Nearest TSS
ENST00000550708/Upstream/5976; ENST00000554046/Downstream/26800;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/17004, chr14-CpG: 90/Downstream/26338
Nearest cancer related gene
CDKN3(OG, No orient, 0)
Upstream sequence
GATAAGTAGGAATTCATCAAATAGAAGAAAAAAGATGAAAATAGCAAAAGGTATAAAATAGTATTAATCTTGCAAAAAGACACTGAAGTGTTCTATCTTG
Downstream sequence
ATCtttttttttttttttaataaggcagttgtctcttctctgtcacccaggctggagtgcagtggcactgtcatagctcactgtagccttgaactgccgg
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate