Basic Information
VIS ID
TVIS44030351
Fusion event
HTLV-1-NOL4 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr18
Cytoband
q12.1
Reference genome
NCBI36/hg18
Start
29788878/33954916 (Hg38)
End
29788878/33954916 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA18A
Target gene
NOL4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-181a-5p ; hsa-mir-4776-3p ; hsa-mir-3972 ; hsa-mir-5006-5p ; hsa-mir-4755-3p ; hsa-mir-1202 ; hsa-mir-129-5p
Nearest miRNA
hsa-mir-1-2/Upstream/3655956; hsa-mir-122/Downstream/1636821;
Nearest TSS
ENST00000575820/Upstream/349275; ENST00000587528/Downstream/68723;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/375893, chr18-CpG: 45/Downstream/204167
Upstream sequence
TAATAAAGACTGAGGTGAAAGAGAGATCCAGATCCCTGAAGTGGAAAAGGTAAAAGAAATGTGAAATCAGCTTAGATATCAAAATTAATAAGGAGGATAC
Downstream sequence
TATGGGATGCAATTAAAAATAAAGATTATAAATAAAGATCTTAGAGAATGTGAATGTAACCTGGGGGATGGTAAATGACAACTATAAGACAGAGGGCAAG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate