Basic Information
VIS ID
TVIS44030392
Fusion event
HTLV-1-NXN integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr17
Cytoband
p13.3
Reference genome
NCBI36/hg18
Start
669763/819773 (Hg38)
End
669763/819773 (Hg38)
Orient
-
Location type
Intronic
Target gene
NXN
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-124-3p ; hsa-mir-1-3p ; hsa-mir-652-3p ; hsa-mir-186-5p ; hsa-mir-92a-3p ; hsa-mir-30c-2-3p ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-7106-5p ; hsa-mir-6825-5p ; hsa-mir-765 ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-4533 ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-6770-5p ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-4779 ; hsa-mir-3929 ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-296-5p ; hsa-mir-4529-5p ; hsa-mir-4707-5p ; hsa-mir-6840-5p ; hsa-mir-4743-5p ; hsa-mir-6510-3p ; hsa-mir-6888-3p ; hsa-mir-1287-3p ; hsa-mir-1273a ; hsa-mir-4522 ; hsa-mir-3120-5p ; hsa-mir-1251-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-6784-5p ; hsa-mir-3613-3p ; hsa-mir-3664-5p ; hsa-mir-5684
Nearest miRNA
hsa-mir-10226/Downstream/202703;
Nearest TSS
ENST00000595228/Upstream/14525; ENST00000573877/Downstream/6228;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/12101, chr17-CpG: 36/Downstream/15855
Upstream sequence
AGGCAACAGGCTATGGGAGTGTGTTATTCTACCCCGGCTGGTGTCCACCAAGAAGCAAATGCCTCCACACAGCAGGTGGGTGCCGGCTAAGACGCCAGCC
Downstream sequence
CACTTCAGCAGCTCCCATCCAGGCAACGCAACTCAGGTCCAACTTTCCATTTCTCAGCACAGACAGGTCTTTCTTGCCTCAGAGCTCAGATGTGCACAGC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate