Basic Information
VIS ID
TVIS44030482
Fusion event
HTLV-1-ITK integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr5
Cytoband
q33.3
Reference genome
NCBI36/hg18
Start
156552443/157192854 (Hg38)
End
156552443/157192854 (Hg38)
Orient
-
Location type
Intronic
Target gene
ITK
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-6083 ; hsa-mir-7111-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-5196-3p ; hsa-mir-3183 ; hsa-mir-3074-3p ; hsa-mir-3591-3p ; hsa-mir-21-3p
Nearest miRNA
hsa-mir-10397/Upstream/2363314; hsa-mir-103a-1/Downstream/3281548;
Nearest TSS
ENST00000502646/Upstream/11987; ENST00000519759/Downstream/29895;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/49798, chr5-CpG: 91/Downstream/72948
Nearest cancer related gene
ITK(OG, No orient, 0)
Upstream sequence
ACTTTCAGGGATCAACAAGTTATCTTCCAACTCTGTGACCCTTCCCCCTGGGATGTAAATTGAATAGTAGAAATGAAAAGACAAAGCCAGTTTAGAAAGT
Downstream sequence
CACCTTGAAAcctcattgtcctcatctctaacattataaagttggactgaatgatttctaaagactcttccagttcAAAAACATGGAAACTtggctcaca
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate