Basic Information
VIS ID
TVIS44030490
Fusion event
HTLV-1-CLNK integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
NCBI36/hg18
Start
10283889/10673167 (Hg38)
End
10283889/10673167 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4A
Target gene
CLNK
miRNAs that regulate target gene
hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-4652-3p ; hsa-mir-629-3p ; hsa-mir-6867-3p ; hsa-mir-4713-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-3682-5p ; hsa-mir-3182 ; hsa-mir-942-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-6832-3p ; hsa-mir-6768-5p ; hsa-mir-8485 ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-1228-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-377-3p ; hsa-mir-4279 ; hsa-mir-4722-3p ; hsa-mir-4740-3p ; hsa-mir-6727-3p ; hsa-mir-6747-3p ; hsa-mir-6778-3p
Nearest miRNA
hsa-mir-3138/Upstream/594475; hsa-mir-12113/Downstream/695660;
Nearest TSS
ENST00000502981/Upstream/16606; ENST00000505494/Downstream/11698;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/211102, chr4-CpG: 74/Downstream/695503
Upstream sequence
TTTCTAATCATGTCAAGCATCAATTTCTCTCTCAGGTCTTATTTATAGGCAGTGAAGAAGTAAAGTCCAGGCTCTTGCAATTGTACAGGGTAGAGTTTAC
Downstream sequence
TACTGTATCTGcaactatttatgaggctttacaatgtgccagtcacgttccagatcctaggaatTAGAGAGCATAGAGCATAAGGTATTATGGGAACACA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate