Basic Information
VIS ID
TVIS44030505
Fusion event
HTLV-1-FMNL2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
q23.3
Reference genome
NCBI36/hg18
Start
153023595/152458835 (Hg38)
End
153023595/152458835 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
FMNL2
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-1-3p ; hsa-mir-93-5p ; hsa-mir-1229-3p ; hsa-mir-203a-3p ; hsa-mir-3609 ; hsa-mir-548ah-5p ; hsa-mir-4536-5p ; hsa-mir-137 ; hsa-mir-4704-5p ; hsa-mir-4796-3p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-6868-3p ; hsa-mir-6875-3p ; hsa-mir-6820-3p ; hsa-mir-3164 ; hsa-mir-3118 ; hsa-mir-134-5p ; hsa-mir-3124-3p ; hsa-mir-4778-3p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-3607-5p ; hsa-mir-4501 ; hsa-mir-96-3p ; hsa-mir-889-3p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-5580-3p ; hsa-mir-944 ; hsa-mir-1277-5p
Nearest miRNA
hsa-mir-128-1/Upstream/1090424; hsa-mir-10b/Downstream/6728000;
Nearest TSS
ENST00000437798/Upstream/123598; ENST00000492942/Downstream/119786;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/122375, chr2-CpG: 169/Downstream/258394
Upstream sequence
gtggcccCACGTGATGCTGTGCGGGAAACTCCTTGAGGGAGGATAATTGACCTTTCACCCAGAGTGATAGGCATCATGCTTTACATGTAGGTGGAGGTTA
Downstream sequence
TTATATTTCTGGGAAACGATACCAGTTTTCTGAAGGCAAGTTTTAATGAAGAGAGTGTGTCTTGTGGGAAGTGTGTAATAGAGTTAAGGGCACCAAACTG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate