VISDB - VIS Detail

Basic Information

VIS ID

TVIS44030563

Fusion event

HTLV-1-MCC integration

Validated

Detection method

HTS

Data source

Curated

Sample type

Nontumor

Disease

Not given

Quality evaluation

Normal

Reported year

2019

PubMed ID

30307560

Virus Sequence

Virus name

HTLV-1

Subtype

HTLV-1c

Reference genome

KF242506

Host Sequence

Chromosome

chr5

Cytoband

q22.2

Reference genome

NCBI36/hg18

Start

112604172/113240576 (Hg38)

End

112604172/113240576 (Hg38)

Orient

Location type

Intronic

Target gene

MCC

miRNAs that regulate target gene

hsa-mir-9-5p ; hsa-mir-26b-5p ; hsa-mir-494-3p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-219b-5p ; hsa-mir-3973 ; hsa-mir-5692a ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-2355-5p ; hsa-mir-1306-5p ; hsa-mir-4687-5p ; hsa-mir-548aw ; hsa-mir-4451 ; hsa-mir-379-5p ; hsa-mir-3529-5p ; hsa-mir-6716-5p ; hsa-mir-4650-3p ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-4790-3p ; hsa-mir-548aj-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-526b-3p ; hsa-mir-20a-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-17-5p ; hsa-mir-301b-3p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-130a-3p ; hsa-mir-130b-3p ; hsa-mir-301a-3p ; hsa-mir-3666 ; hsa-mir-19b-3p ; hsa-mir-19a-3p

Nearest miRNA

hsa-mir-10397/Upstream/2726661; hsa-mir-103a-1/Downstream/3015167;

Nearest TSS

ENST00000502646/Upstream/5899; ENST00000416046/Downstream/54362;

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/263267, chr5-CpG: 37/Downstream/53946

Nearest cancer related gene

MCC(TSG, No orient, 0)

Upstream sequence

AACTGAACAGGACATAAGTCGATGGCATGATTCATGATATCCACTCTAGCATATGTAGCTTGACTCCACTGAATCCACTCCCCTTCCTCTGATACGTCTT

Downstream sequence

CTTTAATACATCAGTGGCACTATTTACAGCAAGGATGGTTTCAATGGAGGTTGCTTTAATATTACATTTCCCTTCCTTCAAGAGTCTAATGCCAACTGTA

Reference

Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.