Basic Information
VIS ID
TVIS44030622
Fusion event
HTLV-1-NAV2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
NCBI36/hg18
Start
19702330/19724208 (Hg38)
End
19702330/19724208 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
NAV2
miRNAs that regulate target gene
hsa-mir-663a ; hsa-mir-98-5p ; hsa-mir-16-5p ; hsa-mir-6825-5p ; hsa-mir-7106-5p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-3202 ; hsa-mir-3179 ; hsa-mir-6876-5p ; hsa-mir-4779 ; hsa-mir-4476 ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6835-3p ; hsa-mir-4668-5p ; hsa-mir-1298-5p ; hsa-mir-664a-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6759-5p ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-2117 ; hsa-mir-6793-5p ; hsa-mir-6748-5p ; hsa-mir-597-3p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-299-3p ; hsa-mir-6818-3p ; hsa-mir-6888-3p ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-3120-5p ; hsa-mir-335-3p ; hsa-mir-664b-3p ; hsa-mir-5696 ; hsa-mir-579-3p ; hsa-mir-627-3p
Nearest miRNA
hsa-mir-210/Upstream/148836; hsa-let-7a-2/Downstream/35796;
Nearest TSS
ENST00000527297/Upstream/10611; ENST00000534229/Downstream/53594;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/10417, chr11-CpG: 44/Downstream/52783
Upstream sequence
atctgttcccatagctccattgtacagatgaagaaaccatgacccagagaggagtgtgacttgcctccagtcacccagctccaaagagcagagtaaaaac
Downstream sequence
cagaacccaagccttctgactGTGGACCAGTATTTTCATCTCAGTTAGTAATCAGATGTTCTGCTCTGAAAGGCCTGATAGCTTAAAGATTGGAACCAGC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate