Basic Information
VIS ID
TVIS44030669
Fusion event
HTLV-1-MCTP1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr5
Cytoband
q15
Reference genome
NCBI36/hg18
Start
94629486/95268026 (Hg38)
End
94629486/95268026 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5B
Target gene
MCTP1
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-4446-5p ; hsa-mir-510-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-6505-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-642a-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-6832-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-203a-3p
Nearest miRNA
hsa-mir-10397/Upstream/1647238; hsa-mir-103a-1/Downstream/811112;
Nearest TSS
ENST00000502646/Upstream/101851; ENST00000506418/Downstream/15974;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/648888, chr5-CpG: 161/Downstream/15729
Upstream sequence
CCAGAACTGTCTGCCACATCCCTGCCTTCCCTCCACCCTGAAGAAATCTGACCAACTCCTATTAGTTATTTTCATTCGATCCTAAATGCTTCTTCAGGGA
Downstream sequence
AACCTGATCTGATCCTCCCTCTCTCAAGATTGGGTTGGGACTTCTTATCATACAATTCATTCCTACAATTCTCTGTACTCCTCTGATTCAGTTATCACAA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate