Basic Information
VIS ID
TVIS44030710
Fusion event
HTLV-1-TNKS integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr8
Cytoband
p23.1
Reference genome
NCBI36/hg18
Start
9492723/9597803 (Hg38)
End
9492723/9597803 (Hg38)
Orient
+
Location type
Intronic
Target gene
TNKS
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-744-5p ; hsa-mir-324-3p ; hsa-mir-324-5p ; hsa-mir-142-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-4693-5p ; hsa-mir-3607-3p ; hsa-mir-1183 ; hsa-mir-1277-5p
Nearest miRNA
hsa-mir-3674/Upstream/549285; hsa-mir-10400/Downstream/143869;
Nearest TSS
ENST00000518652/Upstream/22796; ENST00000521039/Downstream/17487;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/41220, chr8-CpG: 60/Downstream/300864
Upstream sequence
CTCATGAGTAAGCAGCTCTCTTTCAAGCCAAGAGACATCACAGTTGCTGTTTCTGAAAATTGTAACCCACTAGGAATGAGACAAGGAAAAGGACAGATGA
Downstream sequence
GGAATTATGTTAAAAGAAAAAGGTGGTCTTTTCCTCAATGTGGGGGAAAAGTTGAGGTGGGAAGTGAAATATGTGATTCAATACTATCATTCAGAACAAT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate