Basic Information
VIS ID
TVIS44030729
Fusion event
HTLV-1-TLN2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr15
Cytoband
q22.2
Reference genome
NCBI36/hg18
Start
60715623/62636132 (Hg38)
End
60715623/62636132 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA15A
Target gene
TLN2
miRNAs that regulate target gene
hsa-mir-194-5p ; hsa-mir-132-3p ; hsa-mir-4314 ; hsa-mir-6508-3p ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-378g ; hsa-mir-4486 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-4328 ; hsa-mir-25-5p ; hsa-mir-658 ; hsa-mir-6087 ; hsa-mir-6804-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p
Nearest miRNA
hsa-mir-10393/Upstream/292994; hsa-mir-11181/Downstream/187825;
Nearest TSS
ENST00000557528/Upstream/46452; ENST00000474847/Downstream/9049;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/243935, chr15-CpG: 21/Downstream/61583
Upstream sequence
tcagtgccttaacataaaaagggcttagcatcagtgccaggcgcgtaatcacttacatgtgttagctgctactatATACttaaaatttttaaaaatatat
Downstream sequence
GTATGTATTAGTTTTAATTCTTACATTCAGAAGGATGGGAAAATTACAGCAAGGATTTACATAACCTGTAGAGAACTAGACTTAATGACTTCTAAGTCTA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate