Basic Information
VIS ID
TVIS44030836
Fusion event
HTLV-1-GPC5 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr13
Cytoband
q31.3
Reference genome
NCBI36/hg18
Start
91727812/92277558 (Hg38)
End
91727812/92277558 (Hg38)
Orient
+
Location type
Intronic
Target gene
GPC5
miRNAs that regulate target gene
hsa-mir-217 ; hsa-mir-190b ; hsa-mir-190a-5p ; hsa-mir-20a-3p ; hsa-mir-186-5p ; hsa-mir-3133 ; hsa-mir-5582-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-6868-3p ; hsa-mir-6749-3p ; hsa-mir-642a-5p ; hsa-mir-3124-3p ; hsa-mir-4469 ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-5193 ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-6809-3p ; hsa-mir-1238-3p ; hsa-mir-4753-3p ; hsa-mir-670-3p ; hsa-mir-942-5p ; hsa-mir-130b-5p ; hsa-mir-4637 ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-297
Nearest miRNA
hsa-mir-1297/Upstream/926167; hsa-mir-1267/Downstream/212605;
Nearest TSS
ENST00000623511/Upstream/552500; ENST00000618283/Downstream/63045;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/878096, chr13-CpG: 139/Downstream/949434
Nearest cancer related gene
GPC5(TSG, No orient, 0)
Upstream sequence
TAGCTTGTAATTAGTGGAAGGTAATATTATACATCACTTATTATTTTACCCAAGTGCAGAAAACATCTCAAGTTCAAGAGTATATGTAAATTGATGATGC
Downstream sequence
ATTTCCTCCTCTGCTGCTAATAAAAAGATCAATAGAATAAGAATATATTAAAATTTAATACTAAGCATTTTTTTACTTTGTTTTTTATCGTTGCTGTTGG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate