Basic Information
VIS ID
TVIS44030842
Fusion event
HTLV-1-CCDC142 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
p13.1
Reference genome
NCBI36/hg18
Start
74553768/74473133 (Hg38)
End
74553768/74473133 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
CCDC142
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-615-3p ; hsa-mir-221-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-6741-3p ; hsa-mir-183-5p ; hsa-mir-5197-5p ; hsa-mir-4474-3p ; hsa-mir-6805-3p ; hsa-mir-5691 ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-431-5p ; hsa-mir-6879-3p ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-3194-3p ; hsa-mir-924 ; hsa-mir-4524a-3p ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-500b-3p ; hsa-mir-512-3p ; hsa-mir-5007-5p ; hsa-mir-4797-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/4220128; hsa-mir-10b/Downstream/617679;
Nearest TSS
ENST00000437798/Upstream/446; ENST00000463704/Downstream/189;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/351, chr2-CpG: 96/Downstream/8904
Upstream sequence
GGCTTCTTCCAAAGAGAGAGCACTAACACAAGCCGGGATGATCCACACCAGAAGGTAAACACCATTCAGGTAACTGAAGATTAAACGTAGTGAGCTCTGA
Downstream sequence
ATAGCCAAAGCTTAAACGTGAAAGTACTACAGCCCAATATTAGTAAATGACTGAAAATAGTAATAGGAAGGGCAGTACAGGGTAATACTGTCCTTGGGGC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate