Basic Information
VIS ID
TVIS44030853
Fusion event
HTLV-1-SEMA5A integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr5
Cytoband
p15.31
Reference genome
NCBI36/hg18
Start
9132203/9079091 (Hg38)
End
9132203/9079091 (Hg38)
Orient
+
Location type
Intronic
Target gene
SEMA5A
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-218-5p ; hsa-mir-6811-5p ; hsa-mir-6511b-5p ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6836-5p ; hsa-mir-6132 ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-100-3p ; hsa-mir-4270 ; hsa-mir-4709-3p ; hsa-mir-4645-3p ; hsa-mir-3185 ; hsa-mir-144-3p ; hsa-mir-8077 ; hsa-mir-496 ; hsa-mir-216a-5p ; hsa-mir-548c-3p ; hsa-mir-4695-3p ; hsa-mir-4772-3p ; hsa-mir-6787-3p ; hsa-mir-1304-3p ; hsa-mir-660-3p ; hsa-mir-6736-3p ; hsa-mir-6890-3p ; hsa-mir-4714-3p
Nearest miRNA
hsa-mir-4277/Upstream/25196; hsa-mir-10397/Downstream/1323273;
Nearest TSS
ENST00000502646/Upstream/77317; ENST00000511310/Downstream/186454;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/620931, chr5-CpG: 138/Downstream/465489
Upstream sequence
taaaaaatataaatacagaaactataaatataaataaaaataaaTGTGAATCGCATGGCTTAAATATATACCAACTTGCTTTTTACCTGAAAATTAATGG
Downstream sequence
CAAATAATTTAAATACCATTTTCCTCTCCTAGATCATTTGGATGCCATTTAAAATTTTTTGCTTTTTAAAACTaacactccttagcaaatgcaaaagaac
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate