Basic Information
VIS ID
TVIS44030865
Fusion event
HTLV-1-LRRC8D integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr1
Cytoband
p22.2
Reference genome
NCBI36/hg18
Start
90061621/89823474 (Hg38)
End
90061621/89823474 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1D
Target gene
LRRC8D
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-454-3p ; hsa-mir-615-3p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-181d-5p
Nearest miRNA
hsa-mir-101-1/Upstream/3465787; hsa-mir-11399/Downstream/4023358;
Nearest TSS
ENST00000473358/Upstream/1553; ENST00000414841/Downstream/10219;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1546, chr1-CpG: 62/Downstream/19806
Upstream sequence
CCTTTTCCCTTAATTTTTATATTATGCAGCATTTTTAAAAATTAATTTTAGAAAATTCTGATGTGTTTGTCATGTCCAAATAGTTAAATTGTTTTGGTAG
Downstream sequence
CTATAGTTTGGAAATTAGACTCGATTCTGTTCTCAGTACTGTAGACAAAATAGCTATTAAAGTCAAAAGTTTGTCAAAACTTTGTAATCATGATTATTAT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate