Basic Information
VIS ID
TVIS44030879
Fusion event
HTLV-1-IRS1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
q36.3
Reference genome
NCBI36/hg18
Start
227328045/226755085 (Hg38)
End
227328045/226755085 (Hg38)
Orient
-
Location type
Intronic
Target gene
IRS1
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-7-5p ; hsa-mir-126-3p ; hsa-mir-148a-3p ; hsa-mir-152-3p ; hsa-mir-105-5p ; hsa-mir-4480 ; hsa-mir-4311 ; hsa-mir-1277-5p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-4789-3p ; hsa-mir-5580-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-8485 ; hsa-mir-329-3p ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-3120-3p ; hsa-mir-4777-3p ; hsa-mir-892c-3p ; hsa-mir-4676-3p ; hsa-mir-452-5p ; hsa-mir-429 ; hsa-mir-200c-3p ; hsa-mir-200b-3p ; hsa-mir-1225-5p ; hsa-mir-144-3p ; hsa-mir-628-5p ; hsa-mir-384
Nearest miRNA
hsa-mir-10b/Upstream/96292; hsa-mir-1244-1/Downstream/717047;
Nearest TSS
ENST00000437798/Upstream/569714; ENST00000607970/Downstream/40161;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1172070, chr2-CpG: 74/Downstream/36102
Upstream sequence
TTTGACAAACACAAACAGCCAAAAGGTAAAGCGTGAGGCCTGACATTTATTGATCCCATAAAATAGAAACCCTTTTAGCTCTCCTGCCACACTGCATGAC
Downstream sequence
CTGGTAGGCATGGGGATATTTTTATTCAACAGCTTTCCTTCGGTCCTTCCATCCTTTTTTAGAAAGCCAAAATAAAAACCAGAAAAGGCATACTTATAAA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate