Basic Information
VIS ID
TVIS44030899
Fusion event
HTLV-1-PRICKLE2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr3
Cytoband
p14.1
Reference genome
NCBI36/hg18
Start
64258117/64297401 (Hg38)
End
64258117/64297401 (Hg38)
Orient
-
Location type
Intronic
Target gene
PRICKLE2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-5089-3p ; hsa-mir-5093 ; hsa-mir-4468 ; hsa-mir-219a-2-3p ; hsa-mir-219b-3p ; hsa-mir-4680-5p ; hsa-mir-4680-3p ; hsa-mir-6826-5p ; hsa-mir-4496 ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-4703-5p ; hsa-mir-3942-5p ; hsa-mir-4724-5p ; hsa-mir-3646 ; hsa-mir-421 ; hsa-mir-505-3p ; hsa-mir-7159-5p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-4272 ; hsa-mir-6074 ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-5692a ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-203a-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p
Nearest miRNA
hsa-let-7g/Upstream/3679531; hsa-mir-12124/Downstream/2928063;
Nearest TSS
ENST00000440867/Upstream/29227; ENST00000487097/Downstream/147830;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/29258, chr3-CpG: 73/Downstream/147508
Upstream sequence
ggcaacaataccatttgggggaaaacaccaggctggccaaattaaaaaaaaaaaaagaacttaaaagtctagagaatgagatgagtatagagagctttgt
Downstream sequence
aaagttccaatatactcctggggacttagaaagtcaagagtatgcaaaagactgtgcacatgcctgtcgaaagacttaaggttcaaatcactcacttcta
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate