Basic Information
VIS ID
TVIS44030913
Fusion event
HTLV-1-chr1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr1
Cytoband
q23.3
Reference genome
NCBI36/hg18
Start
159322548/161086134 (Hg38)
End
159322548/161086134 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105371471 ; NECTIN4
miRNAs that regulate target gene
hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-4775 ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-590-3p ; hsa-mir-31-3p ; hsa-mir-128-3p
Nearest miRNA
hsa-mir-101-1/Upstream/1186055; hsa-mir-1182/Downstream/141052;
Nearest TSS
ENST00000473358/Upstream/1669; ENST00000471613/Downstream/3465;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/6187, chr1-CpG: 68/Downstream/12138
Nearest cancer related gene
NECTIN4(OG, No orient, 0)
Upstream sequence
TCCCTTCCCTTCTGACTTCGTTCCCCACATCACCTCCATCCCTTCTCTCTGCCTAGACTTCGGTCAGAGCAAGGGCAAGTTTTTGGAGGCTAGAACATCC
Downstream sequence
AATCATTCTCTCCTCACTGGGCCCCAAAGTAGCTAATCCCCATTCACTTTGCCTAGAGGACCCCCAGATCCTGAGGCTCTGGTCTGGCTGATGGAATCAT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate