Basic Information
VIS ID
TVIS44030932
Fusion event
HTLV-1-LIN9 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr1
Cytoband
q42.12
Reference genome
NCBI36/hg18
Start
224539500/226285176 (Hg38)
End
224539500/226285176 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
LIN9
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-30c-5p ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-6729-5p ; hsa-mir-4649-5p ; hsa-mir-661 ; hsa-mir-4252 ; hsa-mir-4537 ; hsa-mir-4486 ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-1292-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-1273g-3p ; hsa-mir-5586-3p ; hsa-mir-508-5p ; hsa-mir-4316 ; hsa-mir-3188 ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-2467-5p ; hsa-mir-3975 ; hsa-mir-337-3p ; hsa-mir-6504-3p ; hsa-mir-656-3p ; hsa-mir-3121-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p
Nearest miRNA
hsa-mir-101-1/Upstream/363034; hsa-mir-1182/Downstream/1656414;
Nearest TSS
ENST00000473358/Upstream/59673; ENST00000467495/Downstream/23895;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/60997, chr1-CpG: 134/Downstream/23484
Nearest cancer related gene
LIN9(TSG, No orient, 0)
Upstream sequence
CTATAAGATTAAATAATGTTATGGTAAGAGAATAGAAGATCAATTAACGAGAAATATTATGACACTCAAACTACAGAACTATGACAAAACAGTAAATAGT
Downstream sequence
GACCAATATCCCACTCTGATGGACAATAATTAGAAACAGTGTAACTCAATTTGCTCAAACACGCAAAATGATAGCAAAAAGTCACCAAATGGCTACTGTA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate