Basic Information
VIS ID
TVIS44030951
Fusion event
HTLV-1-CNTNAP5 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
q14.3
Reference genome
NCBI36/hg18
Start
125277568/124803521 (Hg38)
End
125277568/124803521 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
CNTNAP5
miRNAs that regulate target gene
hsa-mir-574-5p ; hsa-mir-210-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-190a-3p ; hsa-mir-1277-5p ; hsa-mir-4789-5p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-466 ; hsa-mir-4264 ; hsa-mir-4797-3p ; hsa-mir-16-1-3p ; hsa-mir-1285-5p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-3680-5p ; hsa-mir-4798-3p ; hsa-mir-5580-3p ; hsa-mir-4643 ; hsa-mir-4789-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/11082153; hsa-mir-10b/Downstream/2620016;
Nearest TSS
ENST00000437798/Upstream/581816; ENST00000430692/Downstream/907448;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/777843, chr2-CpG: 51/Downstream/1852599
Upstream sequence
TTTCTATTCTTCCATCATCTTCTTTGTTGATAGAAATGCAAAGTCAAATTTAGAATATGCACTAACTCTAGGGCTATCCATCTATGGTGAAATCCTTTGG
Downstream sequence
GTACACAATCCAAATATGGTTCCCAGATCACCTTCTGGGGAGGCTGTGCAGCTGCCCTCCAGCACCAAATGGTTTGTCTGACTTTGCTTCAGGATTTCCT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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