Basic Information
VIS ID
TVIS44030955
Fusion event
HTLV-1-PTPN4 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
q14.2
Reference genome
NCBI36/hg18
Start
120265326/119791280 (Hg38)
End
120265326/119791280 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
PTPN4
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-148a-3p ; hsa-mir-93-5p ; hsa-mir-19b-3p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-4670-3p ; hsa-mir-4709-5p ; hsa-mir-520h ; hsa-mir-3973 ; hsa-mir-520g-3p ; hsa-mir-512-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-4803 ; hsa-mir-4796-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-142-5p ; hsa-mir-5590-3p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-17-5p ; hsa-mir-106a-5p ; hsa-mir-3666 ; hsa-mir-4295 ; hsa-mir-454-3p ; hsa-mir-130a-3p ; hsa-mir-301a-3p ; hsa-mir-301b-3p ; hsa-mir-8061 ; hsa-mir-4760-5p ; hsa-mir-489-3p ; hsa-mir-3144-3p ; hsa-mir-376a-5p ; hsa-mir-4766-5p ; hsa-mir-2054 ; hsa-mir-627-3p ; hsa-mir-429 ; hsa-mir-200c-3p ; hsa-mir-200b-3p ; hsa-mir-8084 ; hsa-mir-5089-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6778-3p ; hsa-mir-4707-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-18a-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-150-5p ; hsa-mir-186-3p ; hsa-mir-6504-3p ; hsa-mir-4438 ; hsa-mir-4698
Nearest miRNA
hsa-mir-1285-2/Upstream/6069912; hsa-mir-10b/Downstream/7632257;
Nearest TSS
ENST00000437798/Upstream/31005; ENST00000433888/Downstream/86043;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/30846, chr2-CpG: 102/Downstream/221541
Upstream sequence
gtgcagtggcacaatctcagctcattgcaacttctgcctcctgggttcaagcgattctcctgcctcagcctcccgagtagctgggactacaggcatgtgc
Downstream sequence
cactatgcccagctactttttgtatttttagtagagatggggtttcaccatgttggttggccaggatggtctcaatctcttgaccttgtgatctacccac
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate