Basic Information
VIS ID
TVIS44030990
Fusion event
HTLV-1-ARHGEF26 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr3
Cytoband
q25.2
Reference genome
NCBI36/hg18
Start
155419171/154218692 (Hg38)
End
155419171/154218692 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA3D
Target gene
ARHGEF26
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-130a-3p ; hsa-mir-188-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-1260a ; hsa-mir-3121-3p ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-4295 ; hsa-mir-4301 ; hsa-mir-3666 ; hsa-mir-4452 ; hsa-mir-3974 ; hsa-mir-4671-3p ; hsa-mir-3591-5p ; hsa-mir-4473 ; hsa-mir-506-3p ; hsa-mir-124-3p ; hsa-mir-3119 ; hsa-mir-216a-5p ; hsa-mir-216b-5p ; hsa-mir-22-3p ; hsa-mir-3679-3p ; hsa-mir-545-5p ; hsa-mir-548c-3p ; hsa-mir-6758-5p ; hsa-mir-6856-5p ; hsa-mir-6873-5p ; hsa-mir-7705 ; hsa-mir-329-5p
Nearest miRNA
hsa-let-7g/Upstream/2652697; hsa-mir-1224/Downstream/5063954;
Nearest TSS
ENST00000440867/Upstream/97252; ENST00000483068/Downstream/7093;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/96101, chr3-CpG: 49/Downstream/209866
Upstream sequence
ACTCTATTGTTTTATAACTTGTAAATGTAATTAAACAATTTTAAATGACTGGTCATATTTTTCCCTAGTAAAAGTGTTTCTATTTCATGCAGTCAAATTA
Downstream sequence
TAGTGATCAGCATTTCATGGTATTCTGTAAAGAGCAGATTCTCTGCCATGTCATGTAGTTTGAGGATTACTGCATGCTTGCTTTGGCAGCATATATACTA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate