Basic Information
VIS ID
TVIS44030999
Fusion event
HTLV-1-GAB1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr4
Cytoband
q31.21
Reference genome
NCBI36/hg18
Start
144487322/143346719 (Hg38)
End
144487322/143346719 (Hg38)
Orient
-
Location type
Intronic
Target gene
GAB1
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-mir-181d-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-409-3p
Nearest miRNA
hsa-mir-12113/Upstream/3184; hsa-mir-1305/Downstream/3061864;
Nearest TSS
ENST00000502981/Upstream/9541; ENST00000515388/Downstream/30106;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/8785, chr4-CpG: 107/Downstream/166377
Upstream sequence
ATTACCTCATTCAGCTAGGGAGGTATTTTTTGAACCCTCTACCCTCTGGCAAAGTTATAATTGACCCCAAAGTTATGTAGGATTATTTACTTTACATGTT
Downstream sequence
CTTGACAGTTTCAGGTTTAAATGTTTGAAGTGTTGAGAAAAGGTAAAAGGAAATATTGAACTCCTAATAATGTAAAATATTTGGGAAGGTACTTTGTTCC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate