Basic Information
VIS ID
TVIS44031113
Fusion event
HTLV-1-SMURF1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
NCBI36/hg18
Start
98558886/99123327 (Hg38)
End
98558886/99123327 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
SMURF1
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-140-5p
Nearest miRNA
hsa-mir-10525/Upstream/241598; hsa-mir-10399/Downstream/285845;
Nearest TSS
ENST00000635602/Upstream/41900; ENST00000471960/Downstream/20692;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/87646, chr7-CpG: 92/Downstream/20128
Nearest cancer related gene
SMURF1(OG, No orient, 0)
Upstream sequence
AAATGGCAATAAAAAAATAAATATTATggccagggcgtggtggcttacgcctgtaattccagcactttgggaggctgagaggatcactagagaccaggag
Downstream sequence
ttcgagaccagcctgggcaacattgtgagaccctgtctctataaaaaattaaacaattagccgggcatggtagtgcacacctgtagtcccagctactcag
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate