Basic Information
VIS ID
TVIS44031145
Fusion event
HTLV-1-KLF9 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr9
Cytoband
q21.12
Reference genome
NCBI36/hg18
Start
72210477/70405741 (Hg38)
End
72210477/70405741 (Hg38)
Orient
+
Location type
Intronic
Target gene
KLF9
miRNAs that regulate target gene
hsa-mir-200c-3p ; hsa-mir-335-5p ; hsa-mir-130b-3p ; hsa-mir-124-3p ; hsa-mir-221-3p ; hsa-mir-218-5p ; hsa-mir-93-5p ; hsa-mir-33a-5p ; hsa-mir-21-5p ; hsa-mir-155-5p ; hsa-mir-607 ; hsa-mir-511-5p ; hsa-mir-431-5p ; hsa-mir-5087 ; hsa-mir-4748 ; hsa-mir-4464 ; hsa-mir-570-5p ; hsa-mir-30a-5p ; hsa-mir-140-3p ; hsa-mir-500b-3p ; hsa-mir-6750-3p ; hsa-mir-6784-3p ; hsa-mir-6862-3p
Nearest miRNA
hsa-mir-101-2/Upstream/29171906; hsa-let-7a-1/Downstream/404234;
Nearest TSS
ENST00000422679/Upstream/59349; ENST00000436491/Downstream/8883;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/146393, chr9-CpG: 161/Downstream/6673
Upstream sequence
AAGTCAATTATACCACACTAGAAACTGAGATTAAAAGAGAAGGCTTCGGGCACACCATCAAAAAGGCTTTGGACACACATGGCAATGAATGGCCTTGGAA
Downstream sequence
GGTCCCATGTATTTAAAAAAAAAATGGGTGCTTCTCACTCCCTCAGGGGGGATCACATTCTTATGAATAATAATGTTAGTCCTATTATTTGCTGAGGGGA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate