Basic Information
VIS ID
TVIS44031204
Fusion event
HTLV-1-PICALM integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr11
Cytoband
q14.2
Reference genome
NCBI36/hg18
Start
85432490/86043800 (Hg38)
End
85432490/86043800 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11F
Target gene
PICALM
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-98-5p ; hsa-mir-30a-5p ; hsa-mir-889-3p ; hsa-mir-3158-5p ; hsa-mir-205-5p ; hsa-mir-17-3p ; hsa-mir-1205 ; hsa-mir-1184 ; hsa-mir-3121-3p ; hsa-mir-30d-5p ; hsa-mir-30e-5p ; hsa-mir-30c-5p ; hsa-mir-30b-5p ; hsa-mir-510-3p ; hsa-mir-5007-3p ; hsa-mir-3163 ; hsa-mir-4760-3p
Nearest miRNA
hsa-mir-10392/Upstream/4152964; hsa-let-7a-2/Downstream/234533;
Nearest TSS
ENST00000527297/Upstream/21331; ENST00000533228/Downstream/24980;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/108652, chr11-CpG: 56/Downstream/24883
Upstream sequence
CTCATAAGATCCAGGAGACAGAAGTAAGGGTAACAGCGAAAAAGCCTTCCCTGTAGGTAGGTTAAAGTTTTTCGTTAAGAGCCAAACCCATGTCTAAATT
Downstream sequence
AAGTAGGAATCCAGAAGATTTTTCATCTCTTCTCTTAAAAATTTTTAAATTCTGCCCAGTCACAGGGAATAATGGATTGCAGTTAGACTCTCTGCCAGAG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate