Basic Information
VIS ID
TVIS44031303
Fusion event
HTLV-1-SLFN13 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr17
Cytoband
q12
Reference genome
NCBI36/hg18
Start
30795775/35444643 (Hg38)
End
30795775/35444643 (Hg38)
Orient
-
Location type
Intronic
Target gene
SLFN13
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-6887-3p ; hsa-mir-4477a ; hsa-mir-216b-3p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-6836-3p ; hsa-mir-5001-3p ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-6778-3p ; hsa-mir-665 ; hsa-mir-6513-3p ; hsa-mir-8062 ; hsa-mir-5089-5p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-150-5p ; hsa-mir-6747-3p ; hsa-mir-186-3p ; hsa-mir-1207-3p
Nearest miRNA
hsa-mir-1180/Upstream/3094441; hsa-mir-10226/Downstream/1589102;
Nearest TSS
ENST00000595228/Upstream/689; ENST00000587076/Downstream/1367;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/36803, chr17-CpG: 18/Downstream/3907
Upstream sequence
AGAATAAAGAAGGAAGTGGTATTGGGGAAGAGGTAGAAAGGTCAGGAAGGGAGAATCTGGTTCCCTCTTACCTGGATCTGCGTCCATCATTTTCTCTACC
Downstream sequence
CATTCCTCAGTTGTCAAGGGGCGGATGTACTTCTCCCTCACCATCCATGACTTGGGAGCTTCCGAGAACACCACACAACAGAATGCCTTCACTTTAATCA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate