Basic Information
VIS ID
TVIS44031307
Fusion event
HTLV-1-TMEM220 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
NCBI36/hg18
Start
10569429/10725387 (Hg38)
End
10569429/10725387 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA17A
Target gene
TMEM220
miRNAs that regulate target gene
hsa-mir-5696 ; hsa-mir-4729 ; hsa-mir-95-5p ; hsa-mir-3121-3p ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-548c-3p ; hsa-mir-4668-5p ; hsa-mir-3613-3p ; hsa-mir-4279 ; hsa-mir-6749-3p ; hsa-mir-6796-3p ; hsa-mir-3646
Nearest miRNA
hsa-mir-1253/Upstream/2538383; hsa-mir-10226/Downstream/1356512;
Nearest TSS
ENST00000595228/Upstream/253; ENST00000583115/Downstream/978;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/27505, chr17-CpG: 76/Downstream/4085
Upstream sequence
AGGTCACAGCACTAATTATAAACTTCagtggccatttcttgtttgggttgttcagcagctccccttcctaggatgattacccttattttctctggggatc
Downstream sequence
caccatgtccacactcacagtccatgtTTCCCAGTGAACTGGACTTTGGCTAGGTCAATCAATACATGTTATCTCCTCAGCCACAGTGATTTGGATCAGC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate