Basic Information
VIS ID
TVIS44031325
Fusion event
HTLV-1-PHLDB3 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr19
Cytoband
q13.31
Reference genome
NCBI36/hg18
Start
48697883/43501891 (Hg38)
End
48697883/43501891 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
PHLDB3
miRNAs that regulate target gene
hsa-mir-331-3p ; hsa-mir-15b-5p
Nearest miRNA
hsa-mir-10395/Upstream/1150686; hsa-let-7e/Downstream/1151795;
Nearest TSS
ENST00000633603/Upstream/4063; ENST00000600154/Downstream/2523;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/26359, chr19-CpG: 78/Downstream/1971
Upstream sequence
CGCAGCTGCTCCTCCTCCCGGCGAGCGGCCACTCGCTCCCCAGCCAGCTCACCCCGCAGCAAGGCCACCTCCACCTCCATCTGCGGAGAGAATGCCAGGG
Downstream sequence
CTGGGGGCTCGGACGCCTAGGTCCAAGGAAGAGGCCCAGGGCCTGAACTACCGGATTCGAAGGGAGGATGGACTCCAGGGACCTGAATTTGGAGGGAGGA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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