Basic Information
VIS ID
TVIS44031326
Fusion event
HTLV-1-PLEKHA4 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr19
Cytoband
q13.33
Reference genome
NCBI36/hg18
Start
54060703/48865634 (Hg38)
End
54060703/48865634 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
PLEKHA4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p
Nearest miRNA
hsa-mir-10395/Upstream/1638613; hsa-let-7e/Downstream/144272;
Nearest TSS
ENST00000633603/Upstream/77; ENST00000600406/Downstream/1961;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/28117, chr19-CpG: 46/Downstream/6593
Upstream sequence
GAAGGTTGGGATCCCTCCTGAGCGCATTGCCTCTCTTCCCAAAGGCGTGGATCTTGTTTACTGCCCGGGTGGGCTTCTGAGGAGAGAAGGGGACAGAAGT
Downstream sequence
GAACAGGGAGAGCCTAGGATGGTCCTGGGAGGGGGTGAGGGTGGACACAGGCAACCGTAGGCTCTCGCTTGGCTGCCCTGAGAAATGGGTCAAGGACCag
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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