Basic Information
VIS ID
TVIS44031329
Fusion event
HTLV-1-POU2F2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
NCBI36/hg18
Start
47352965/42156973 (Hg38)
End
47352965/42156973 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
POU2F2
miRNAs that regulate target gene
hsa-mir-9-5p ; hsa-mir-4768-5p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-190a-3p ; hsa-mir-4307 ; hsa-mir-5011-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-6832-3p ; hsa-mir-410-3p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-6755-5p ; hsa-mir-6841-5p ; hsa-mir-6512-5p ; hsa-mir-6768-3p ; hsa-mir-6888-3p ; hsa-mir-6794-3p ; hsa-mir-3120-5p ; hsa-mir-1304-3p ; hsa-mir-3162-3p ; hsa-mir-4639-3p ; hsa-mir-510-5p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-504-5p ; hsa-mir-6839-3p ; hsa-mir-659-3p ; hsa-mir-29b-2-5p ; hsa-mir-4753-3p ; hsa-mir-130b-5p ; hsa-mir-218-5p ; hsa-mir-129-5p ; hsa-mir-133a-3p ; hsa-mir-133b ; hsa-mir-3124-3p ; hsa-mir-323b-5p ; hsa-mir-410-5p ; hsa-mir-494-5p ; hsa-mir-6843-3p ; hsa-mir-6848-3p ; hsa-mir-92a-1-5p
Nearest miRNA
hsa-mir-10395/Upstream/23460; hsa-let-7e/Downstream/194158;
Nearest TSS
ENST00000633603/Upstream/4404; ENST00000597945/Downstream/19052;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/23441, chr19-CpG: 32/Downstream/20179
Upstream sequence
GGATGAAAGCCGCTCACCTAGAGCAAAGCTTCTGCTTCCGAGGCATTCAGGACTCCCCTCAGGGTGTGTGAGCACCCTGGGGCACATGCCTGTTGCTTAT
Downstream sequence
GTCTGGGTTACCTCTGTGACCCTGGGACCGCTCCACATTGAAGGCCGTTGTGTCTTTTTGTGGAAGGATGGAAGGACAGAAGGGAAGGAGAGACAAAGTG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate