Basic Information
VIS ID
TVIS44031401
Fusion event
HTLV-1-PAK1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr11
Cytoband
q13.5
Reference genome
NCBI36/hg18
Start
76738328/77349635 (Hg38)
End
76738328/77349635 (Hg38)
Orient
-
Location type
Intronic
Target gene
PAK1
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-377-3p ; hsa-mir-122-5p ; hsa-mir-26b-5p ; hsa-mir-423-5p ; hsa-mir-320a ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-221-3p ; hsa-mir-548c-3p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-4744 ; hsa-mir-216a-5p ; hsa-mir-3133 ; hsa-mir-34b-3p ; hsa-mir-98-5p ; hsa-mir-30c-5p
Nearest miRNA
hsa-mir-10392/Upstream/2014449; hsa-let-7a-2/Downstream/2052387;
Nearest TSS
ENST00000527297/Upstream/89; ENST00000598970/Downstream/6316;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/169695, chr11-CpG: 33/Downstream/62056
Nearest cancer related gene
PAK1(OG, No orient, 0)
Upstream sequence
cttaagaaagttatttaacttctttgagcttcactttcctcatttgtaaagtggacataagagaatacaagataatttaaattgattagttcatgtaaag
Downstream sequence
tacttagccaactgcatatcatataacagatgctcaatatatattaattTCCTGTTCCTGCTTGCTTCTCTCCTCTCCTCCATCacccttggcacgtggc
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate