VISDB - VIS Detail

Basic Information

VIS ID

TVIS44031420

Fusion event

HTLV-1-PAPOLG integration

Validated

Detection method

HTS

Data source

Curated

Sample type

Nontumor

Disease

Not given

Quality evaluation

Normal

Reported year

2019

PubMed ID

30307560

Virus Sequence

Virus name

HTLV-1

Subtype

HTLV-1c

Reference genome

KF242506

Host Sequence

Chromosome

chr2

Cytoband

p16.1

Reference genome

NCBI36/hg18

Start

60882118/60801479 (Hg38)

End

60882118/60801479 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA2S

Target gene

PAPOLG

miRNAs that regulate target gene

hsa-mir-33a-5p ; hsa-mir-16-5p ; hsa-mir-503-5p ; hsa-mir-548e-5p ; hsa-mir-7158-3p ; hsa-mir-203b-3p ; hsa-mir-31-5p ; hsa-mir-1827 ; hsa-mir-4680-5p ; hsa-mir-4649-3p ; hsa-mir-4538 ; hsa-mir-3123 ; hsa-mir-4453 ; hsa-mir-549a ; hsa-mir-586 ; hsa-mir-5700 ; hsa-mir-33b-5p ; hsa-mir-3658 ; hsa-mir-3653-3p ; hsa-mir-5680 ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-6883-3p ; hsa-mir-561-3p ; hsa-mir-7844-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-mir-4789-5p ; hsa-let-7f-2-3p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-653-5p ; hsa-mir-548s ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-653-3p ; hsa-mir-3926 ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-4711-5p ; hsa-mir-7112-3p ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-3190-5p ; hsa-mir-6849-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-1294 ; hsa-mir-4252 ; hsa-mir-455-3p ; hsa-mir-5008-3p ; hsa-mir-5694 ; hsa-mir-6134 ; hsa-mir-6499-3p ; hsa-mir-6516-5p ; hsa-mir-6737-3p ; hsa-mir-7157-3p ; hsa-mir-7854-3p

Nearest miRNA

hsa-mir-1301/Upstream/414034; hsa-mir-10b/Downstream/1404347;

Nearest TSS

ENST00000437798/Upstream/9998; ENST00000642725/Downstream/79835;

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/44744, chr2-CpG: 97/Downstream/79511

Upstream sequence

GTCTCAATAATGGTTTTTTTTTTCCAATTGCATAAGGTCACGTCATCCCCCAAATTGTCTAttttttcttttctttttttttaagatggagtctcgctcc

Downstream sequence

gtcacccaggctggaatgcagtggcgcaatcttggctcattgcaacctccacctcccaggtgcaagcgattctcctacctcagcctcccaagtagctggg

Reference

Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.