Basic Information
VIS ID
TVIS44031455
Fusion event
HTLV-1-TMEM218 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr11
Cytoband
q24.2
Reference genome
NCBI36/hg18
Start
124477888/125102782 (Hg38)
End
124477888/125102782 (Hg38)
Orient
+
Location type
Intronic
Target gene
TMEM218
miRNAs that regulate target gene
hsa-mir-384 ; hsa-mir-3685 ; hsa-mir-503-3p ; hsa-mir-5009-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-4483 ; hsa-mir-1293 ; hsa-mir-5191 ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-302c-5p ; hsa-mir-3143 ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-4803
Nearest miRNA
hsa-let-7a-2/Upstream/1721270; hsa-mir-3167/Downstream/1885676;
Nearest TSS
ENST00000527297/Upstream/18934; ENST00000561399/Downstream/27;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/39021, chr11-CpG: 37/Downstream/8641
Upstream sequence
AGCAGAAGTTGAAGCTCTCAGGTTAAATCCATGGTGTGAGCTGTGACTCACCAGGCAATGGATCACAAGACAGAAAGTTCCCACTCTGTTGTCGAGTTCT
Downstream sequence
TATTCAAGAGGATGAAAACTCCCAGTCCTTAAAGAAGAGGaacagccatcactatttttgaacattcactgtgtgctaagtgccgtacaaacatatctca
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate