Basic Information
VIS ID
TVIS44031476
Fusion event
HTLV-1-AFAP1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
NCBI36/hg18
Start
7894497/7841870 (Hg38)
End
7894497/7841870 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4A
Target gene
AFAP1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-3613-5p ; hsa-mir-2115-5p ; hsa-mir-646 ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-942-3p ; hsa-mir-5582-3p ; hsa-mir-4802-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-578
Nearest miRNA
hsa-mir-378d-1/Upstream/381752; hsa-mir-12113/Downstream/163431;
Nearest TSS
ENST00000502981/Upstream/25822; ENST00000623059/Downstream/1967;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/41157, chr4-CpG: 156/Downstream/96966
Upstream sequence
cttcttattcacaactactcttagtagtaggtattatcatcctggttttgaagggggaaaGCTGGCAGGGGCCCAAATGGAAGACAAAGCaggggagggg
Downstream sequence
ggaagaagttaagaagttagggggtgagggagaggagggcaggggagagggaCCAGGGACTCAGAACCCCAAACTGCTAATCCCTACACACAACCGCGAA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate