VISDB - VIS Detail

Basic Information

VIS ID

TVIS44031485

Fusion event

HTLV-1-PCMTD1 integration

Validated

Detection method

HTS

Data source

Curated

Sample type

Nontumor

Disease

Not given

Quality evaluation

Normal

Reported year

2019

PubMed ID

30307560

Virus Sequence

Virus name

HTLV-1

Subtype

HTLV-1c

Reference genome

KF242506

Host Sequence

Chromosome

chr8

Cytoband

q11.23

Reference genome

NCBI36/hg18

Start

52955696/51880583 (Hg38)

End

52955696/51880583 (Hg38)

Orient

Location type

Intronic

Target gene

PCMTD1

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-4325 ; hsa-mir-7703 ; hsa-mir-190a-3p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-643 ; hsa-mir-5011-5p ; hsa-mir-3120-3p ; hsa-mir-1277-5p ; hsa-mir-137 ; hsa-mir-25-3p ; hsa-mir-32-5p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-4252 ; hsa-mir-7977 ; hsa-mir-4691-3p ; hsa-mir-3618 ; hsa-mir-1283 ; hsa-mir-4709-5p ; hsa-mir-8062 ; hsa-mir-3065-5p ; hsa-mir-570-5p ; hsa-mir-548ba ; hsa-mir-548ai ; hsa-mir-548ag ; hsa-mir-3121-3p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-548n ; hsa-mir-3161 ; hsa-mir-4420 ; hsa-mir-181b-3p ; hsa-mir-181b-2-3p ; hsa-mir-9-3p ; hsa-mir-34c-3p ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p

Nearest miRNA

hsa-mir-124-1/Upstream/8984308; hsa-mir-10400/Downstream/9834205;

Nearest TSS

ENST00000518652/Upstream/19699; ENST00000521612/Downstream/18387;

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/470922, chr8-CpG: 108/Downstream/18027

Upstream sequence

TCTTCCACCTTTATTGGGAACTCTAGCATCTCTACTGTAGTCTTCTCTACTCCCCAACTCATACCATAATCAGGGGCATCCTCAACGTACATGAACAACC

Downstream sequence

TTTTCAATCTCCAAAGGAACAACTATGACACCTTTAACTGAGGACTTATATCACCCAATTGTCCAACCTGAATCCTTACTTTTTTCTCTGACCTGATTTT

Reference

Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.