Basic Information
VIS ID
TVIS44031508
Fusion event
HTLV-1-GOLGA3 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
NCBI36/hg18
Start
131901793/132815134 (Hg38)
End
131901793/132815134 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
GOLGA3
miRNAs that regulate target gene
hsa-mir-32-5p ; hsa-mir-484 ; hsa-mir-99a-5p ; hsa-mir-92a-3p ; hsa-mir-450a-1-3p ; hsa-mir-218-5p ; hsa-mir-4282 ; hsa-mir-7856-5p ; hsa-mir-4477b ; hsa-mir-8064 ; hsa-mir-6814-5p ; hsa-mir-3613-3p ; hsa-mir-651-3p ; hsa-mir-137 ; hsa-mir-367-3p ; hsa-mir-92b-3p ; hsa-mir-25-3p ; hsa-mir-363-3p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-877-3p ; hsa-mir-3186-5p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-4283 ; hsa-mir-4437 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-4284 ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-6499-5p ; hsa-mir-383-3p ; hsa-mir-6813-5p ; hsa-mir-6085 ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-4649-3p ; hsa-mir-490-3p ; hsa-mir-6087 ; hsa-mir-7160-5p
Nearest miRNA
hsa-let-7i/Upstream/233073;
Nearest TSS
ENST00000382841/Upstream/38442; ENST00000424075/Downstream/7177;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/13082, chr12-CpG: 108/Downstream/13160
Upstream sequence
CAGGTAGATGCTGAGGAGATGAGCAGCTACTGTCCTAAATAATCCCTAACATCTGAGCAGTCACCAAGAATTTCACTGTAAATGTACCATTATTAGTTTA
Downstream sequence
TACATTTTATCACTGAAAAGATCTCTAGTCCTTTTCACATGGCAAAGTGGTCCAGATGGCTAGACCGTAAGTGGCAAATTCAGGCCTATGGCCACCAGGC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate