Basic Information
VIS ID
TVIS44031539
Fusion event
HTLV-1-NEDD4L integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr18
Cytoband
q21.31
Reference genome
NCBI36/hg18
Start
54025198/58206968 (Hg38)
End
54025198/58206968 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA18B
Target gene
NEDD4L
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-mir-1296-5p ; hsa-mir-423-5p ; hsa-mir-7855-5p ; hsa-mir-6807-5p ; hsa-mir-7843-3p ; hsa-mir-4710 ; hsa-mir-4792 ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-2467-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-1827 ; hsa-mir-4487 ; hsa-mir-558 ; hsa-mir-3160-3p ; hsa-mir-5186 ; hsa-mir-4786-3p ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-4257 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-4695-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-6504-3p ; hsa-mir-656-3p ; hsa-mir-5011-5p ; hsa-mir-93-3p ; hsa-mir-30a-5p ; hsa-mir-376c-3p
Nearest miRNA
hsa-mir-1-2/Upstream/2727670; hsa-mir-122/Downstream/244106;
Nearest TSS
ENST00000575820/Upstream/9199; ENST00000585323/Downstream/14567;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/11327, chr18-CpG: 96/Downstream/48787
Nearest cancer related gene
NEDD4L(TSG, No orient, 0)
Upstream sequence
GGCACCTTCATCGGCAGTTGGGGTACACCACTTGCTACAGTGTGATGGAATAAGGGACGATCCAAAGGCACTCAGTTCTCCCACCCATCCTGTGCACAAG
Downstream sequence
GAAAAGACCTTTGAATTGTGTCTCCCCTGTTGTCCTTTGCATTGTGAAAGTGCATATTAGTTCTCCCATCCACTCTTTTCTCTTTAAGCTTTAGCATACG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate