Basic Information
VIS ID
TVIS44031572
Fusion event
HTLV-1-MAP3K4 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr6
Cytoband
q26
Reference genome
NCBI36/hg18
Start
161416320/161075298 (Hg38)
End
161416320/161075298 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6E
Target gene
MAP3K4
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-148a-3p ; hsa-mir-93-5p ; hsa-mir-92a-3p ; hsa-mir-199a-3p ; hsa-mir-199b-3p ; hsa-mir-1245a ; hsa-mir-3123 ; hsa-mir-3129-5p ; hsa-mir-3691-3p ; hsa-mir-6073 ; hsa-mir-8062 ; hsa-mir-8079 ; hsa-mir-144-3p ; hsa-mir-101-3p
Nearest miRNA
hsa-mir-10398/Upstream/2310545; hsa-mir-1913/Downstream/5434056;
Nearest TSS
ENST00000381078/Upstream/1969; ENST00000540205/Downstream/5385;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/82766, chr6-CpG: 76/Downstream/570587
Nearest cancer related gene
MAP3K4(TSG, No orient, 0)
Upstream sequence
gactgaaacgcagtggtgtgttgacggcttcctgtagtctcaacctactgggctcaaacgatcctcctgcctcagcctccctaataactgggaccacagg
Downstream sequence
cgtgtgccaccacacctggctaatttttaaaaatttttttgtagagtcagggtctcactatgttgcccaggctggtcttgaactcctgggctcagtgatc
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate