Basic Information
VIS ID
TVIS44031588
Fusion event
HTLV-1-PIKFYVE integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
q34
Reference genome
NCBI36/hg18
Start
208842163/208269194 (Hg38)
End
208842163/208269194 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2I
Target gene
PIKFYVE
miRNAs that regulate target gene
hsa-mir-744-5p ; hsa-mir-324-3p ; hsa-mir-328-3p ; hsa-mir-100-5p ; hsa-mir-26a-5p ; hsa-mir-509-5p ; hsa-mir-509-3-5p ; hsa-mir-4418 ; hsa-mir-376a-3p ; hsa-mir-7156-3p ; hsa-mir-7977 ; hsa-mir-1184 ; hsa-mir-1304-3p ; hsa-mir-4267 ; hsa-mir-6890-3p ; hsa-mir-508-3p
Nearest miRNA
hsa-mir-10b/Upstream/514313; hsa-mir-1244-1/Downstream/4157069;
Nearest TSS
ENST00000437798/Upstream/2831; ENST00000477200/Downstream/29447;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/2782, chr2-CpG: 29/Downstream/91053
Upstream sequence
CCTTCCAGGATTGTAAGAGTAAAATGAGATGGTAGCTATGATTTTGAATGTGAAAAGCATTTTACCGAGACTGTAATGTCCTCTTTGTAAAGTGGAGACT
Downstream sequence
AGATTATAAACTATAGTATATATATTGTTTTCTCCAAGGGAGGAACCTTGTCTTTATTTTGAAACAGTAGGTAGCCTCCTGGTGGCTGGAACATGCTTCT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate