Basic Information
VIS ID
TVIS44031591
Fusion event
HTLV-1-TMEM131L integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr4
Cytoband
q31.3
Reference genome
NCBI36/hg18
Start
154638205/153497603 (Hg38)
End
154638205/153497603 (Hg38)
Orient
-
Location type
Intronic
Target gene
TMEM131L
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-26b-5p ; hsa-mir-744-5p ; hsa-mir-335-3p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-5007-3p ; hsa-mir-5092 ; hsa-mir-3163 ; hsa-mir-513b-3p ; hsa-mir-548n ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-606 ; hsa-mir-4684-5p ; hsa-mir-3675-3p ; hsa-mir-4724-5p ; hsa-mir-216b-5p ; hsa-mir-3150b-5p ; hsa-mir-3150a-5p
Nearest miRNA
hsa-mir-12113/Upstream/961087; hsa-mir-1305/Downstream/5631199;
Nearest TSS
ENST00000502981/Upstream/31254; ENST00000462540/Downstream/56578;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/30140, chr4-CpG: 95/Downstream/186331
Upstream sequence
TTTGAAACGTTTTGCTCTCCATAGAATTGTGTACCAGGAGAGTTATATTGATTAAATTAGGTCTTACATTTTATGTTATATATTCAGAGACATATATTTG
Downstream sequence
TAGTCTGCATTTCAGGTAAAGCGTTTTCCATGTTGGAGGTCAAATCCCACGAGGTTCACGTATCTATTGCTGCTGCTTTACCCTGTTCTGGAAAAGAAAG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate