VISDB - VIS Detail

Basic Information

VIS ID

TVIS44031594

Fusion event

HTLV-1-NR6A1 integration

Validated

Detection method

HTS

Data source

Curated

Sample type

Nontumor

Disease

Not given

Quality evaluation

Normal

Reported year

2019

PubMed ID

30307560

Virus Sequence

Virus name

HTLV-1

Subtype

HTLV-1c

Reference genome

KF242506

Host Sequence

Chromosome

chr9

Cytoband

q33.3

Reference genome

NCBI36/hg18

Start

126363131/124561031 (Hg38)

End

126363131/124561031 (Hg38)

Orient

Location type

Intronic

Target gene

NR6A1

miRNAs that regulate target gene

hsa-mir-421 ; hsa-mir-9-5p ; hsa-mir-181a-5p ; hsa-mir-218-5p ; hsa-mir-632 ; hsa-mir-4288 ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-346 ; hsa-mir-6508-3p ; hsa-mir-17-3p ; hsa-mir-1205 ; hsa-mir-1184 ; hsa-mir-646 ; hsa-mir-4257 ; hsa-mir-503-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-let-7e-5p ; hsa-mir-98-5p ; hsa-let-7c-5p ; hsa-mir-4500 ; hsa-let-7i-5p ; hsa-let-7a-5p ; hsa-mir-4458 ; hsa-let-7g-5p ; hsa-let-7d-5p ; hsa-let-7f-5p ; hsa-let-7b-5p ; hsa-mir-6864-5p ; hsa-mir-6126 ; hsa-mir-4440 ; hsa-mir-4493 ; hsa-mir-605-3p ; hsa-mir-4272 ; hsa-mir-5011-5p ; hsa-mir-15a-3p ; hsa-mir-3664-5p ; hsa-mir-1277-5p ; hsa-mir-4753-5p ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-1289 ; hsa-mir-196a-5p ; hsa-mir-196b-5p ; hsa-mir-1972 ; hsa-mir-2467-3p ; hsa-mir-3158-5p ; hsa-mir-3174 ; hsa-mir-3678-3p ; hsa-mir-3927-3p ; hsa-mir-4496 ; hsa-mir-4645-5p ; hsa-mir-4673 ; hsa-mir-4691-5p ; hsa-mir-4731-5p ; hsa-mir-4736 ; hsa-mir-486-3p ; hsa-mir-561-5p ; hsa-mir-6073 ; hsa-mir-654-3p ; hsa-mir-6721-5p ; hsa-mir-6830-5p ; hsa-mir-6831-5p ; hsa-mir-7844-5p ; hsa-mir-921

Nearest miRNA

hsa-let-7a-1/Upstream/1075409; hsa-mir-12126/Downstream/131411;

Nearest TSS

ENST00000422679/Upstream/44975; ENST00000429139/Downstream/34777;

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/55651, chr9-CpG: 144/Downstream/208730

Upstream sequence

AATCAAGGGGACAGGCTTGGGTGGCAATGTAGAGTTGATCTCAGAGCCCATGGCAAGGTAAGCCTCAACTTGTGGATAGAAAAGAAAATGACAGGCTGAG

Downstream sequence

CACCGTAGTCCCAGCACTTTGTAAGAGTGAGCACTTAGATGTACCTCTGTTTCTCTTCTATAGAATGTGGatattatattatattaaattatattaATAA

Reference

Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.