Basic Information
VIS ID
TVIS44031596
Fusion event
HTLV-1-IKZF5 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr10
Cytoband
q26.13
Reference genome
NCBI36/hg18
Start
124749289/122999783 (Hg38)
End
124749289/122999783 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
IKZF5
miRNAs that regulate target gene
hsa-mir-935 ; hsa-mir-20a-5p ; hsa-mir-580-3p ; hsa-mir-526b-5p ; hsa-mir-4533 ; hsa-mir-6124 ; hsa-mir-539-5p ; hsa-mir-6876-5p ; hsa-mir-1252-5p ; hsa-mir-4476 ; hsa-mir-651-3p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-8078 ; hsa-mir-1287-3p ; hsa-mir-520h ; hsa-mir-3973 ; hsa-mir-520g-3p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-3692-3p ; hsa-mir-550b-3p ; hsa-mir-1228-3p ; hsa-mir-501-5p ; hsa-mir-500b-5p ; hsa-mir-362-5p ; hsa-mir-6074
Nearest miRNA
hsa-mir-107/Upstream/582716; hsa-mir-202/Downstream/2033000;
Nearest TSS
ENST00000439456/Upstream/16493; ENST00000411816/Downstream/8904;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/19007, chr10-CpG: 88/Downstream/8459
Upstream sequence
TATCCACTCCAAGACTAGGGAAAAATAAAAAAGTAAAAGAAAATCCCTGACCGTAGTgtagaaagggaaagtctcttgtgtgttctgcaatcacaagctg
Downstream sequence
gtcttcacataggtttatggcccaaattcacaAATAAAATAGCCAAAAAAGTTTTCTAGTAAGAATAAGATGAAGTCTAGCACCTGGGATAAAAAAGGTC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate