Basic Information
VIS ID
TVIS44031612
Fusion event
HTLV-1-CUL5 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
NCBI36/hg18
Start
107429298/108053361 (Hg38)
End
107429298/108053361 (Hg38)
Orient
+
Location type
Intronic
Target gene
CUL5
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-148b-3p ; hsa-mir-375 ; hsa-mir-215-5p ; hsa-mir-484 ; hsa-mir-100-5p ; hsa-mir-92a-3p ; hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181d-5p ; hsa-mir-7-5p ; hsa-mir-205-5p ; hsa-mir-142-3p ; hsa-mir-182-5p
Nearest miRNA
hsa-mir-10392/Upstream/4203381; hsa-let-7a-2/Downstream/3294396;
Nearest TSS
ENST00000527297/Upstream/7091; ENST00000531843/Downstream/20029;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/43689, chr11-CpG: 71/Downstream/67916
Nearest cancer related gene
CUL5(TSG, No orient, 0)
Upstream sequence
agttaacttctctcatttagtgcttcacagtacctgtgcctccttggCATAGTACTTTTGTTTAATTGTGTTGTTAGCACCATGTCTTTACTGAACATAG
Downstream sequence
AATGCATGGCACAAAATCACTCTAGGTAGGTATTTATTGAGTTAATGAACCTATAGAGTTACTTTTGACTGGCTTTTCTTCATGGCCCCCATATTCTTTT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate