Basic Information
VIS ID
TVIS44031622
Fusion event
HTLV-1-ZDHHC2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr8
Cytoband
p22
Reference genome
NCBI36/hg18
Start
17067249/17165369 (Hg38)
End
17067249/17165369 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZDHHC2
miRNAs that regulate target gene
hsa-mir-132-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-541-5p ; hsa-mir-578 ; hsa-mir-4762-3p ; hsa-mir-127-5p ; hsa-mir-7843-3p ; hsa-mir-526b-5p ; hsa-mir-4303 ; hsa-mir-5186 ; hsa-mir-4635 ; hsa-mir-6761-5p ; hsa-mir-4329 ; hsa-mir-4251 ; hsa-mir-1279 ; hsa-mir-487a-3p ; hsa-mir-154-3p
Nearest miRNA
hsa-mir-124-1/Upstream/2311859; hsa-mir-10400/Downstream/516209;
Nearest TSS
ENST00000518652/Upstream/2570; ENST00000517334/Downstream/42644;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/8088, chr8-CpG: 73/Downstream/81186
Nearest cancer related gene
ZDHHC2(TSG, No orient, 0)
Upstream sequence
GTTTTAGGAATAAAGGCAGTCAGGGATTTATGTACTTAACTATGACTAGTGATTAGCCAGGGCATCTTCAGAGAGGTCAGTGAATGGGAAAAGATAAAGG
Downstream sequence
GCAGGGACCAGTTTGACTTAATCAAGGTCTTAATTGTAGCATATTTTAATGAAATGCAACTTACTCCAGGACTAATACCTGCTGAAAATTAAGATATACC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate