Basic Information
VIS ID
TVIS44031635
Fusion event
HTLV-1-UNC5C integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr4
Cytoband
q22.3
Reference genome
NCBI36/hg18
Start
96544108/95403934 (Hg38)
End
96544108/95403934 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
UNC5C
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-4477b ; hsa-mir-488-3p ; hsa-mir-4496 ; hsa-mir-323a-3p ; hsa-mir-651-3p ; hsa-mir-6762-3p ; hsa-mir-93-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-500a-5p ; hsa-mir-222-5p ; hsa-mir-6806-5p ; hsa-mir-5088-3p ; hsa-mir-3129-5p ; hsa-mir-199b-3p ; hsa-mir-199a-3p ; hsa-mir-936
Nearest miRNA
hsa-mir-12113/Upstream/8103351; hsa-mir-1243/Downstream/3593453;
Nearest TSS
ENST00000502981/Upstream/68302; ENST00000605849/Downstream/145038;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/645276, chr4-CpG: 20/Downstream/144371
Nearest cancer related gene
UNC5C(TSG, No orient, 0)
Upstream sequence
GTAATCAATAGGAGGGTATTTCCGAAGAGGCCAGTGTGGCTCACAGATGGATCGTTTTCCAGCCATTGAAAGCTACCTTGGGGGAAGGAAACTACTTAGC
Downstream sequence
CTCCTGTGTGGTGAGTACATTAGACATACATAACACAATAATTAAATTGATGAACAGTCAATAGACTCTAAAGGCCTGGGAGGGAAAAACCAAAAAGCAT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate