Basic Information
VIS ID
TVIS44031651
Fusion event
HTLV-1-PXK integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr3
Cytoband
p14.3
Reference genome
NCBI36/hg18
Start
58294148/58333381 (Hg38)
End
58294148/58333381 (Hg38)
Orient
+
Location type
Intronic
Target gene
PXK
miRNAs that regulate target gene
hsa-mir-744-5p ; hsa-mir-4503 ; hsa-mir-488-3p ; hsa-mir-6792-5p ; hsa-mir-6730-5p ; hsa-mir-5681a ; hsa-mir-501-5p ; hsa-mir-500a-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-4796-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-519d-3p ; hsa-mir-526b-3p ; hsa-mir-3666 ; hsa-mir-4295 ; hsa-mir-301b-3p ; hsa-mir-130a-3p ; hsa-mir-130b-3p ; hsa-mir-454-3p ; hsa-mir-301a-3p ; hsa-mir-4309 ; hsa-mir-3198 ; hsa-mir-4653-3p ; hsa-mir-101-5p ; hsa-mir-548p ; hsa-mir-577 ; hsa-mir-513b-3p ; hsa-mir-4662a-3p ; hsa-mir-548m ; hsa-mir-489-3p ; hsa-mir-526b-5p ; hsa-mir-578
Nearest miRNA
hsa-let-7g/Upstream/2480787; hsa-mir-12124/Downstream/2284424;
Nearest TSS
ENST00000440867/Upstream/75; ENST00000459676/Downstream/62293;
Nearest CpG islands
chr3-CpG: 80/Target, None/Upstream, None/Downstream
Upstream sequence
GGCCCGGAGGGGCCAAGGATGGGGACCGCAGCTCCCGGCGCCGCGGGGTGGAAGGAGCTCGGCGGCGACCAGGAAAGCGACTCCGAGTTGGGGGGCGGGG
Downstream sequence
GCGGGGGCTGCGGGATTCCCGGGCTCACCTTGGACTAGGGGAGCAGGAACGAGACCGCTCAGGACCATCCACTTCTGCCCGCCGCCAGCCTTTTCCTTTT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate