Basic Information
VIS ID
TVIS44031680
Fusion event
HTLV-1-ATRNL1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr10
Cytoband
q25.3
Reference genome
NCBI36/hg18
Start
117579310/115829809 (Hg38)
End
117579310/115829809 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
ATRNL1
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-379-3p ; hsa-mir-3613-3p ; hsa-mir-3163 ; hsa-mir-577 ; hsa-mir-6771-3p ; hsa-mir-4282 ; hsa-mir-548as-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac
Nearest miRNA
hsa-mir-107/Upstream/1655630; hsa-mir-202/Downstream/997679;
Nearest TSS
ENST00000439456/Upstream/362635; ENST00000449616/Downstream/79542;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/735474, chr10-CpG: 18/Downstream/295493
Upstream sequence
TTCTTTTCCTTTATGGTTTTGGAGACTCCCCAAGAGCTAAAGCAGAAAAAAATCAACACTAGATGGCCCTAGAAGATGTACTCTTCATGGTTTTGTCTCT
Downstream sequence
TGTCTGACTGCCCGGAGAAGAGTTCCTTAGGCATTTACAAACACAGCAATGCCACCTTTTAGCCCCACTCTTTAGGGATTTTACATGACTAATTTTAATT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate